Gentamicin assays for once daily dosing (5mg/kg) in adults: Target range and results interpretation.

• The target range for the "Pre-dose" is <1.0 mg/L.
• Normal pre-dose level:
  • The regimen of 5 mg/kg once daily can be continued. 
  • A further "pre-dose" level should be performed following 3-4 more doses so long as renal function is stable.
• Pre-dose level is between 1-2 mg/L (and renal function unchanged)
  • Increase the dosing interval to 36 hourly.
• Pre-dose level is >2 mg/L 
  • Further gentamicin doses should be withheld until discussed with microbiology  
  • The need for gentamicin therapy should be reviewed.

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Page last edited: 29/10/2008

Caution; the antibiotic doses recommended on this website are intended for adult patients with normal renal and liver function unless otherwise stated. Dosing advice for patients with renal impairment is available here.

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